Extra-Adrenal Glucocorticoid Synthesis in Mucosal Tissues and Its Implication in Mucosal Immune Homeostasis and Tumor Development
نویسندگان
چکیده
© 2012 Brunner et al., licensee InTech. This is an open access chapter distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Extra-Adrenal Glucocorticoid Synthesis in Mucosal Tissues and Its Implication in Mucosal Immune Homeostasis and Tumor Development
منابع مشابه
ASSESSMENT OF TUMOR MARKERS IN BENIGN, DYSPLASTIC AND MALIGNANT ORAL MUCOSAL LESIONS
Immunohistochemical demonstration of tumor-associated markers may be valuable as an adjunct to conventional histology for determination of malignancy development in oral mucosal diseases. Accordingly, the present study determined the distribution of some important tumor markers such as heat shock proteins (HSP), fibroblast growth factors (FGF) and transferrin receptors (TF-R) in 22 samples ...
متن کاملConnexins in respiratory and gastrointestinal mucosal immunity.
The mucosal lining forms the physical and chemical barrier that protects against pathogens and hostile particles and harbors its own population of bacteria, fungi and archea, known as the microbiota. The immune system controls tolerance of this population of microorganisms that have proven to be beneficial for its host. Keeping its physical integrity and a correct balance with the microbiota, t...
متن کاملChitosan-based Nanoparticles in Mucosal Vaccine Delivery
Most infectious diseases are caused by pathogenic infiltrations from the mucosal tract. Nowadays, the use of vaccines has been widely investigated for the prevention of different infectious diseases, infertility, immune disorders, malignancies, and allergies. Broad-spectrum adjuvant substances have been studied for immune system stimulation with a greater efficiency against specific antigens. V...
متن کاملThe nuclear receptor LRH-1 critically regulates extra-adrenal glucocorticoid synthesis in the intestine
The nuclear receptor liver receptor homologue-1 (LRH-1, NR5A2) is a crucial transcriptional regulator of many metabolic pathways. In addition, LRH-1 is expressed in intestinal crypt cells where it regulates the epithelial cell renewal and contributes to tumorigenesis through the induction of cell cycle proteins. We have recently identified the intestinal epithelium as an important extra-adrenal...
متن کاملEpidemiologic Study of the Prevalence of Oral Mucosal Lesions in the Biopsied Samples at Buali and Imam Khomeini Hospitals from 2000 to 2014
Background and Aim: Oral mucosal lesions have various prevalence rates among different populations. Few studies have evaluated the frequency of oral mucosal lesions in Iranian population. This study aimed to determine the frequency of oral mucosal lesions and the related factors. &nb...
متن کامل